Application note: Detecting small amounts of multiple API polymorphic forms in powder blends (pdf)

File size: 237 kB Language: English Part number: AN217(EN)-01-A

Application note:  Detecting small amounts of multiple API polymorphic forms in powder blends

The stability, bioavailability and processability of an active pharmaceutical ingredient (API) are key to a candidate molecule’s
ability to be developed into a commercially viable product. Different drug polymorphs can vary markedly in properties such as their flowability, dissolution rate, solubility, and stability. Characterising the different polymorphic forms of a drug and selecting the optimum polymorph for drug product development have become important considerations in this process. Renishaw’s RA802 Pharmaceutical Analyser was used to detect small amounts of different polymorphic forms (form I and form II) of an active pharmaceutical ingredient (API) in a generic drug powder.

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